Acute heat stress activated inflammatory signaling in porcine oxidative skeletal muscle
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چکیده
منابع مشابه
Acute heat stress activated inflammatory signaling in porcine oxidative skeletal muscle
Despite well-studied clinical manifestations, intracellular mechanisms of prolonged hyperthermic injury remain unclear, especially in skeletal muscle. Given muscle's large potential to impact systemic inflammation and metabolism, the response of muscle cells to heat-mediated injury warrants further investigation. We have previously reported increased activation of NF-κB signaling and increased ...
متن کاملHeat stress causes oxidative stress but not inflammatory signaling in porcine skeletal muscle
Heat stress is associated with death and other maladaptions including muscle dysfunction and impaired growth across species. Despite this common observation, the molecular effects leading to these pathologic changes remain unclear. The purpose of this study was to determine the extent to which heat stress disrupted redox balance and initiated an inflammatory response in oxidative and glycolytic...
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Heat stress causes morbidity and mortality in humans and animals and threatens food security by limiting livestock productivity. Inflammatory signaling may contribute to heat stress-mediated skeletal muscle dysfunction. Previously, we discovered increased circulating endotoxin and intramuscular oxidative stress and TNF-α protein abundance, but not inflammatory signaling following 24 and 72 h of...
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We have previously established that 24 h of environmental hyperthermia causes oxidative stress and have implicated mitochondria as likely contributors to this process. Given this, we hypothesized that heat stress would lead to increased autophagy/mitophagy and a reduction in mitochondrial content. To address this hypothesis pigs were housed in thermoneutral (TN; 20°C) or heat stress (35°C) cond...
متن کاملOxidative stress and skeletal muscle in exercise.
Reactive oxygen species (ROSs) are often associated with damage to cellular functions. ROSs production is indicatives of oxidative stress during physical exercise. Oxidative stress occurs in those circumstances in which free radicals determine a tissue damage or production of toxic and dangerous compounds for tissues. In a relaxation state, antioxidant defense of body may hold under control fre...
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ژورنال
عنوان ژورنال: Physiological Reports
سال: 2017
ISSN: 2051-817X,2051-817X
DOI: 10.14814/phy2.13397